Polymethoxyl flavones are the general name of highly methoxyl oxidized flavonoids unique to citrus of Rutaceae. Studies have shown that polymethoxyflavone has a positive protective effect on the occurrence and development of tumors in colon, skin, lung, liver and other parts. Orange flavone is a natural polymethoxy flavone, which not only exists in the traditional Chinese medicine citrus aurantium and orange peel, but also in citrus and other foods. It is a good potential anti-tumor plant component. Angiogenesis plays an important role in the occurrence and development of tumor, the formation of female physiological cycle, rheumatoid arthritis, asthma and chronic inflammation. Angiogenesis is the expansion and remodeling of the formed vascular network, including dentition, endothelial cell proliferation and directional migration, vascular anastomosis, lumen formation and other processes. In these processes, vascular endothelial cells play an important role, so the study of anti angiogenesis has become one of the hot spots in tumor research.

    Although the content of polymethoxy flavones such as sweet orange yellow ketone is not high, its anti-tumor effect is much stronger than that of general flavones. It is considered that the main reason is that polymethoxy flavones have small polarity and intend to enter cells through cell membrane, thus affecting the growth of tumor cells. The greatest advantage of malignant tumor is the endless and unregulated growth of tumor cells. Therefore, inhibiting the proliferation of gastric cancer cells is an important way to treat gastric cancer, mainly through regulating cell cycle and inducing apoptosis. It was found that orange flavone could inhibit the proliferation of gastric cancer AGS cells, and the inhibitory effect was significantly stronger than that of other dihydroflavones.

    SoOrange flavoneThe anti-tumor effect is mainly achieved by inhibiting angiogenesis, because vascular endothelial cells play an important role in physiological and pathological processes. Despite the wide range of biological effects, the low solubility and bioavailability still greatly limit the clinical use of sweet orange flavonoids. Providing appropriate drug delivery pathway is an effective way to improve its effect. The results showed that chitosan microemulsion injection and self microemulsion drug delivery system could improve the bioavailability of orange flavonoids to a certain extent. Because the anti-tumor research of orange flavonoids is still mainly in vitro, it is necessary to strengthen the research of orange flavonoids on whole animals and pharmacokinetics.