Tacrolimus ointment is a drug that can inhibit local skin immune response. In the past few years, tacrolimus ointment has been successfully used in the treatment of eczema. Tacrolimus ointment may be the latest and most advanced drug for the treatment of vitiligo, which can inhibit the local skin immune response in the leukoplakia area. At present, the approved instructions do not specifically mention the treatment of vitiligo, and the US Food and Drug Administration (FDA) does not support the clinical use and research of putetapex for vitiligo. However, after the investigation and research, many patients hope that the treatment of vitiligo by puterbi will be approved as soon as possible. Most experts believe that vitiligo is caused by the immune system mistakenly attacking the body's own melanocytes. But aboutTacrolimusWhether the ointment has hormones has always been the most concerned issue for patients. According to previous studies, tacrolimus is not a hormone drug.

    First of all, tacrolimus ointment will not be easily absorbed by the blood of the human body. It is a drug that can inhibit the local skin immune response, so that the treatment is really limited to the local area, which makes the patients feel at ease.

    Secondly, tacrolimus ointment is the world's first non glucocorticoid topical immunomodulator, which does not contain hormones. The drug is an immunomodulator, and its structure is macrolide. It has the characteristics of small relative molecular weight and good skin permeability, and is suitable for external use. The mechanism of tacrolimus ointment is to combine with the cytoplasmic proteins of T lymphocytes, inhibit the phosphatase activity of calcineurin phosphatase, and then inhibit the expression and release of various cytokines and inflammatory mediators, resulting in strong anti-inflammatory effect; At the same time, it can promote the synthesis of skin collagen and the recovery of skin barrier function. The drug can not only replace the anti-inflammatory effect of hormone preparations, but also avoid the adverse reactions caused by long-term external use of hormone preparations. It can be seen that tacrolimus ointment does not contain hormones. It is a macrolide external immunomodulator. It is safe and effective in the treatment of atopic dermatitis.

    Finally, tacrolimus is a non steroidal macrolide immunosuppressant. Its immunosuppressive activity is 10 ~ 100 times higher than that of cyclosporin. Its mechanism is mainly to inhibit T cell activity, interfere with cytokine network and regulate th1/th2 ratio, inhibit histamine release from mast cells and basophils, inhibit the survival of serotonin and leukotriene, reduce the level of IL-8 and its receptor in keratinocytes, and inhibit inflammatory response. In addition, in view of its strong anti-inflammatory effect, tacrolimus has been selected to treat itching, redness and inflammation of skin caused by hormone dependent dermatitis with good effect. In particular, the onset time is short, with an average of about 2 days. The effect is faster than the general treatment, and there are fewer adverse reactions. Local irritation symptoms generally occur 1 to 2 days after treatment, and the discomfort gradually reduces or disappears after 2 days. The patients can tolerate it completely. After stopping the drug, there is no aggravation of the original disease or drug dependence.

      To sum up, tacrolimus ointment is not a hormone drug. As long as patients strictly follow the doctor's advice, they will give full play to the role of the drug to a greater extent. It is not safe to use tacrolimus ointment in large doses for a long time.