Chinese people have a long-standing habit of drinking tea, and there are many studies on the active ingredients in tea. Besides catechin, tea polyphenols and other components, theophylline is also one of the active components in tea. Theophylline, a white amorphous crystalline alkaloid contained in tea, is an isomer of theobromine and a smooth muscle relaxant. Its function and structure are similar to caffeine. It can relax smooth muscle, excite cardiac muscle and diuresis.

    SotheophyllineWhat diseases can be treated? Because theophylline is a methylpurine drug. It can strengthen heart, diuresis, dilate coronary artery, relax bronchial smooth muscle and excite central nervous system. Therefore, it is often used to treat bronchial asthma, asthmatic bronchitis, acute cardiac insufficiency, cardiogenic asthma and biliary colic.

    However, theophylline can also produce side effects when used, mainly including nausea, vomiting and dizziness. The occurrence of adverse reactions is closely related to the blood concentration. Toxic reactions can occur when the concentration is greater than 20 μ g/ml. The blood concentration must be monitored during use. The mechanism of its action is complex. It was thought that the increase of intracellular cAMP content was caused by the inhibition of phosphodiesterase. Recent experiments suggest that theophylline's bronchiectasis is partly due to the release of endogenous epinephrine and norepinephrine. In addition, theophylline is a purine receptor blocker, which can resist the contractile effect of adenine on the respiratory tract. Theophylline can enhance the contractility of diaphragm, especially in the case of weak contraction of diaphragm, so it is beneficial to improve respiratory function. However, excessive dosage of theophylline at one time, too fast intravenous injection, or repeated drug use may lead to excessive poisoning. And sometimes poisoning symptoms are not easy to be found, or even misdiagnosed as the original disease itself; Therefore, the dosage of theophylline was further increased by mistake, leading to serious poisoning. Infection can affect theophylline metabolism, increase blood concentration, and even reach the level of poisoning. Other factors that can increase theophylline blood concentration include liver disease, congestive heart failure, respiratory failure, chronic obstructive pulmonary disease, renal failure, metabolic acidosis, high fever, female, young, old and obese. It is emphasized that aminophylline is easy to cause poisoning in the elderly by intravenous injection, so it is not suitable to give it to the elderly by intravenous injection.