Liuwei Dihuang prescription is a classic prescription for nourishing yin and kidney. At present, it is widely used in the treatment of metabolic diseases such as fatty liver, diabetes, hyperlipidemia and atherosclerosis, and has achieved positive effects. Monoglycoside is one of the main chemical components of Liuwei Dihuang pills. It has pharmacological effects of enhancing immunity, anti-inflammatory, bitter tonifying and stomach strengthening, and preventing diabetic vascular diseases. The experimental study found that monooside may be one of the direct acting substances of Liuwei Dihuang pills in vivo. In vitro pharmacological activity studies suggest that a certain concentration of monooside can improve the abnormal differentiation of adipocytes, and then improve the disorder of lipid metabolism. Adipocytes are the main members of adipose tissue. They mainly play the role of storing triglycerides and regulating energy balance in animals. When used, they also have important secretory functions. Adipose tissue is not only a passive energy storage organ, but also an endocrine organ that can secrete a variety of hormones. Abnormal proliferation and differentiation of adipocytes can lead to excessive accumulation of adipose tissue, disorder of adipocyte endocrine function, and then lead to obesity, diabetes, coronary heart disease and other diseases related to insulin resistance.
MonoglycosideIn addition to improving the abnormal differentiation of adipocytes, it also has good pharmacological activity against cerebral ischemia. Stroke is a common acute cerebrovascular disease in clinic. It has the characteristics of high morbidity, high mortality and high disability rate. It has become the first cause of death in China. The mortality rate of patients in China is five times that of the United States and 3.5 times that of Japan. Most survivors are left with hemiplegia, aphasia and other disabilities that seriously affect the quality of life due to brain injury. For a long time, traditional Chinese medicine has a significant clinical effect on stroke, and has become an important research object in the study of brain protective drugs. During the intervention of cerebral ischemia / reperfusion, monoglycoside can produce antioxidant effect by increasing the content of endogenous GSH, inhibit neural apoptosis, and produce neuroprotective effect. It lays a foundation for further study of brain protective drugs.
As one of the direct active substances in Liuwei Dihuang pills, monoglycoside plays an important role and shows good pharmacological activity. Therefore, it is of great significance to develop the related drugs of monoglycoside.