Geranium is also known as five leaf grass, six Yang grass, five petal grass, etc. it has the effects of dispelling wind dampness, activating blood circulation and unblocking collaterals, detoxifying and stopping dysentery. In traditional Chinese medicine, it is used for rheumatic arthralgia, numbness and goucontracture, muscle and bone soreness, and diarrhea dysentery. Old crane grass is rich in tannins. Many of its pharmacological activities are closely related to tannins, which Japanese scholars call Geranium. The prototype compound of Geranium wilfordii is a water-soluble combination of Geranium wilfordii and ascorbic acid. Geranium wilfordii can be decomposed into gallic acid, hexahydroxycloth Biphenyldicarboxylic Acid, ellagic acid, corilagin, yunshiacid and yunshisu.
1. Antioxidation
Geranium, the main tannin in Geranium wilfordii, and its hydrolysates are the main components of antioxidation. Some studies have shown that Geranium wilfordii can reduce the occurrence of experimental hydrochloric acid and alcohol ulcer, and has superoxide dismutase like effect. At the same time, it is also found that Geranium wilfordii can inhibit lipid peroxidation damage, liver mitochondria and microsomes, and VC automatic oxidation and reduction of harmful metal ions. The antioxidant mechanism of Geranium Geranium proved that Geranium Geranium had antioxidant effect by capturing free radicals formed by reaction and forming stable free radicals by itself.
2. Hepatoprotective effect
Studies have shown that Geranium can inhibit the lipid peroxidation of liver mitochondria and microsomes, reduce the levels of plasma cholesterol, got and GPT, and also inhibit the lipid peroxidation of microsomes induced by ADP and NADPH, so as to protect the liver from damage.
3. Anti inflammatory, immune and analgesic effects
Studies have found that Geranium can significantly inhibit the swelling of egg white arthritis in rats, and can significantly inhibit the primary and secondary lesions of adjuvant joints in rats. It shows that Geranium has anti-inflammatory, anti immune and analgesic effects
4. Inhibition of mutagenesis
Geranium has inhibitory effect on Trp-P-2 and other inducers. The hydrolysate of Geranium has significant inhibitory effect on the mutagenic activity of benzopyrene-7,8-diol-9,10-epoxide, the final carcinogen.
5. Geranium has the effect of stopping diarrhea.
6. Effect on kidney
Japanese scholars have studied the effect of Geranium on aminonucleoside puromycin induced glomerulonephritis in rats. Studies have shown that Geranium can inhibit proteinuria in this experimental nephrotic model even after the lesion occurs. As a free radical scavenger, oridonin may play an important role in the inhibition of experimental nephritis.
7. Antibacterial action
Geranium can inhibit Shigella flexneri, Escherichia coli, Staphylococcus aureus and Pseudomonas aeruginosa in vitro.
8. Antiviral effect
GeraniumIt has anti herpes simplex virus effect and can inhibit the replication of many viruses, such as influenza, herpes simplex, cowpox HIV-1， The effect of anti influenza virus is the most obvious, which can reduce the infectivity of various influenza virus strains in vitro.
Geranium, as a widely used tannin, has a good economic value and application prospect for its clinical application and other drug utilization.