Many people do not know the pharmacological action of rosmarinic acid; Here we decrypt for you according to years of R & D experience:
Rosmarinic acid is a water-soluble substance, light yellow powder, mp:192 ℃ ~ 195 ℃, blue-green in the presence of ferric chloride potassium ferricyanide solution.
Bacteriostasis of rosmarinic acid
(1) Bacteriostasis
Rosmarinic acid had significant inhibitory effects on Bacillus subtilis, Staphylococcus aureus and Escherichia coli.
(2) Antifungal
Inhibitory activities of rosmarinic acid on mycelial growth and spore germination of different plant pathogenic fungi.
(3) Inhibition of mold
Rosmarinic acid extracted from plants can inhibit Phytophthora and its spores, which cause soil borne diseases, and effectively reduce the germination of zoospores [2].
Anti inflammatory effect of rosmarinic acid
(1) Anti nephritis effect
Rosmarinic acid can inhibit glomerular mesangial cell proliferation and glomerular inflation.
(2) Antihepatitis effect
Rosmarinic acid can reduce liver injury induced by lipopolysaccharide (LPS) and significantly inhibit the increase of plasma transaminase level, which proves that rosmarinic acid can protect the liver by eliminating or reducing superoxide or nitrite oxide rather than by inhibiting TNF - α [3].
(3) Anti pneumonia effect
Rosmarinic acid inhibits diesel exhaust particulates (DEP) - induced lung injury characterized by neutrophil retention and interstitial edema.
(4) Anti arthritis effect
Rosmarinic acid can inhibit collagen induced arthritis and significantly reduce the number of arthritis and affected joints.
(5) Anti periodontitis effect
Rosmarinic acid can prevent chronic gingivitis by inhibiting the formation of bacterial plaque.
(6) Anti dermatitis effect
Rosmarinic acid can alleviate atopic dermatitis, also known as atopic eczema or hereditary allergic eczema.
Antiviral effect of rosmarinic acid
(1) Anti herpesvirus
Rosmarinic acid shows special activity to herpes simplex virus type I and type II. It is an effective component for controlling herpes. Its antiviral activity can not only inhibit the activity of some enzymes in the virus life cycle, but also quickly combine with the virus coat protein, so as to inactivate the virus.
(2) Anti HIV
Rosmarinic acid can inhibit the activity of HIV-1 (human immunodeficiency virus 1) integrase [4].
(3) Anti encephalitis virus
Rosmarinic acid can reduce the mortality of mice with Japanese encephalitis virus, significantly reduce the viral load, and make the virus difficult to spread.
Anticancer and antitumor effects of rosmarinic acid
Rosmarinic acid inhibits the expression of CCL11 and CCR3 by inhibiting the activity of β - kinase and the genes related to the activation of nuclear factor kappa B, so as to achieve the purpose of anti-tumor.
Anti allergic effect of rosmarinic acid
Rosmarinic acid can inhibit allergic inflammation induced by micro allergens.
Antioxidation of rosmarinic acid
Rosmarinic acid has good free radical scavenging and antioxidant effects.
Antithrombotic and antiplatelet agglutination effects of rosmarinic acid
Rosmarinic acid can inhibit the formation of malondialdehyde in human platelets in vitro, and its IC50 value is 3.37nmol/l, indicating that rosmarinic acid has anti platelet aggregation activity [6].
Antidepressant effect of rosmarinic acid
Radiation and ultraviolet protection of rosmarinic acid
Rosmarinic acid can be used as a light protective agent to prevent radiation and ultraviolet rays
Immunosuppressive effect of rosmarinic acid
(1) Complement inhibition
(2) Lymphocyte inhibition
(3) Inhibition of arachidonic acid metabolism
Effect of rosmarinic acid on nerve
Other effects of rosmarinic acid
(1) Stabilizing effect on color
(2) Inhibition of hyaluronidase
(3) Inhibition of xanthine oxidase
(4) Liver protection
(5) Inhibition of angiogenesis
(6) Prevention of arteriosclerosis
(7) Prevent memory impairment
(8) Used as cosmetic
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