Cerebral ischemia-reperfusion injury
Cerebral ischemia-reperfusion injury (CIRI) is a complex pathophysiological process occurring after restoration of blood flow to ischemic brain tissue. While reperfusion is essential for tissue survival, it paradoxically exacerbates neuronal damage through mechanisms including oxidative stress, inflammation, excitotoxicity, and blood-brain barrier disruption. This secondary injury contributes significantly to neurological deficits and poor outcomes in conditions like ischemic stroke, cardiac arrest, and traumatic brain injury, making it a critical therapeutic target.
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