SERPINA1
SERPINA1, also known as Alpha-1 Antitrypsin (AAT), is a glycoprotein primarily synthesized in the liver. It functions as a serine protease inhibitor, with its main role being the protection of tissues from degradation by neutrophil elastase and other proteases. Genetic mutations in the SERPINA1 gene can lead to Alpha-1 Antitrypsin Deficiency (AATD), a hereditary disorder characterized by reduced AAT levels, predisposing individuals to lung diseases like emphysema and liver disease.
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