KCNH2
KCNH2 (potassium voltage-gated channel subfamily H member 2) is a gene that encodes the alpha subunit of the human Ether-à-go-go-Related Gene (hERG) potassium channel, also known as Kv11.1. This voltage-gated potassium channel is critically involved in cardiac repolarization, specifically contributing to the rapid component of the delayed rectifier potassium current (IKr). Mutations in KCNH2 are a primary cause of congenital Long QT Syndrome type 2 (LQTS2), a disorder predisposing individuals to life-threatening ventricular arrhythmias.
