NEK7
NEK7 (NIMA-related kinase 7) is a serine/threonine protein kinase involved in essential cellular processes, including cell cycle regulation, mitosis, and inflammation. It plays a critical role in inflammasome activation, particularly the NLRP3 inflammasome, by interacting with NLRP3 to facilitate its oligomerization and subsequent caspase-1 activation. Dysregulation of NEK7 is implicated in various inflammatory diseases, cancers, and neurodegenerative disorders, making it a potential therapeutic target.
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