OPRK1
OPRK1 encodes the Kappa Opioid Receptor 1 (KOR1), a G protein-coupled receptor primarily involved in mediating the analgesic, sedative, and dysphoric effects of opioid compounds, particularly dynorphins. It plays a crucial role in pain modulation, stress responses, and addiction pathways. KOR1 activation can lead to hyperpolarization of neurons and inhibition of neurotransmitter release, contributing to its diverse physiological and pharmacological actions. Dysregulation of OPRK1 is implicated in various neurological and psychiatric conditions.
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