NR1H2
NR1H2, also known as Liver X Receptor Beta (LXRβ), is a nuclear receptor that plays a crucial role in regulating cholesterol, fatty acid, and glucose homeostasis. It functions as a ligand-activated transcription factor, forming heterodimers with retinoid X receptors (RXRs) to bind to specific DNA sequences (LXREs) and modulate gene expression. NR1H2 is widely expressed and involved in lipid metabolism, inflammation, and immune responses, making it a significant target in metabolic and inflammatory diseases.
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