F2
Factor II, also known as prothrombin, is a vitamin K-dependent glycoprotein synthesized in the liver. It is a crucial zymogen in the coagulation cascade, serving as the precursor to thrombin (Factor IIa). Upon activation by Factor Xa, prothrombin is cleaved to form thrombin, which then converts fibrinogen to fibrin, leading to clot formation. Genetic variations in the F2 gene, such as the G20210A mutation, are associated with an increased risk of venous thromboembolism.
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