BRCA1
BRCA1 (BReast CAncer gene 1) is a human tumor suppressor gene that plays a critical role in DNA repair, maintaining genomic stability. Mutations in BRCA1 are associated with an increased risk of hereditary breast cancer, ovarian cancer, prostate cancer, and pancreatic cancer. Its protein product participates in homologous recombination, ensuring accurate repair of double-strand DNA breaks. Genetic testing for BRCA1 mutations is crucial for risk assessment and guiding personalized prevention and treatment strategies in affected individuals and families.
