DPP4
Dipeptidyl peptidase-4 (DPP4), also known as CD26, is a ubiquitously expressed serine protease found on cell surfaces and in soluble form. It plays a crucial role in glucose homeostasis by inactivating incretin hormones, such as GLP-1 and GIP, which stimulate insulin secretion. Inhibition of DPP4 activity prolongs the action of incretins, leading to improved glycemic control, making it a significant therapeutic target for type 2 diabetes mellitus. Beyond its metabolic functions, DPP4 is involved in immune regulation and various physiological processes.
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