SLC6A4
SLC6A4 (Solute Carrier Family 6 Member 4) encodes the serotonin transporter (SERT), a crucial integral membrane protein responsible for reuptake of serotonin from the synaptic cleft into presynaptic neurons. This process regulates serotonin levels, influencing neurotransmission. Genetic variations in SLC6A4 are associated with susceptibility to various psychiatric disorders, including depression, anxiety, and obsessive-compulsive disorder, and can impact response to antidepressant medications like SSRIs.
