MAPK8
MAPK8, also known as JNK1 (c-Jun N-terminal kinase 1), is a serine/threonine protein kinase that plays a crucial role in cellular responses to various extracellular stimuli, including environmental stress, inflammatory cytokines, and growth factors. It is involved in regulating cell proliferation, differentiation, survival, and apoptosis, making it a significant target in diseases such as cancer, neurodegenerative disorders, and inflammatory conditions. MAPK8 phosphorylates transcription factors like c-Jun, activating gene expression.
