SLC1A3
SLC1A3, also known as EAAT3 or GLAST, encodes a high-affinity glutamate transporter protein primarily expressed in astrocytes of the central nervous system. This transporter plays a crucial role in maintaining low extracellular glutamate concentrations, thereby preventing excitotoxicity and regulating synaptic transmission. Dysregulation of SLC1A3 has been implicated in various neurological conditions, including epilepsy, stroke, and neurodegenerative diseases, making it a significant target for therapeutic research.
