SLC5A2
SLC5A2 encodes the sodium-glucose cotransporter 2 (SGLT2), a crucial protein primarily expressed in the renal proximal tubules. SGLT2 is responsible for reabsorbing approximately 90% of the glucose filtered by the kidneys, returning it to the bloodstream. Inhibition of SGLT2, through therapeutic agents, leads to increased urinary glucose excretion, lowering blood glucose levels. This mechanism makes SLC5A2 a significant therapeutic target for type 2 diabetes mellitus and associated conditions.
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