LOX-1
Lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1), encoded by the OLR1 gene, is a major receptor for oxidized low-density lipoprotein (oxLDL). Expressed on endothelial cells, macrophages, and smooth muscle cells, LOX-1 plays a critical role in the pathogenesis of atherosclerosis, inflammation, and thrombosis. Its activation by oxLDL contributes to endothelial dysfunction, foam cell formation, and plaque instability, making it a significant therapeutic target in cardiovascular diseases.
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