| Catalog No | Package | Original Price | Price | Inventory | Quantity | Operating |
|---|---|---|---|---|---|---|
| BP0096-5mg | 5mg | $250.00 | Sign in |
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Product name: Isomucronulatol
Synonym name:
Catalogue No.: BP0096
Cas No.: 64474-51-7
Formula: C17H18O5
Mol Weight: 302.326
Botanical Source:
Type of Compound:
Purity: 95%~99%
Analysis Method: HPLC-DAD or/and HPLC-ELSD
Identification Method: Mass, NMR
Packing: Brown vial or HDPE plastic bottle
Storage: Store in a well closed container, protected from air and light. Put into refrigerate or freeze for long term storage.
Whenever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20℃. Generally, these will be useable for up to two weeks.
The product could be supplied from milligrams to grams
Inquire for bulk scale.
For Reference Standard and R&D, Not for Human Use Directly.
Storage conditions：Short-term storage at 2~8℃, long-term storage at -20 ~ -80℃
69.1700
2.3500
2.1200
Low
.7500
No
No
No
No
No
No
Isomucronulatol (CAS number: 64474-51-7) is a natural flavonoid product derived from the roots of traditional Chinese medicine Astragalus membranaceus. As a member of the flavonoid family, isoquercetin has gradually attracted attention in the field of pharmacology due to its unique chemical structure and biological activity. In recent years, with the deepening of research on the anti-inflammatory and anti-tumor mechanisms of natural products, isomorphol has shown potential value in regulating inflammatory responses and various disease-related signaling pathways, especially in the prevention and treatment of precancerous lesions such as adenomas.
This review will systematically summarize the chemical structure and physicochemical properties, plant sources, and extraction methods of isoquercetin, with a focus on its pharmacological activity and mechanism of action. Combined with modern pharmacological evaluation systems, it will explore its clinical application potential and future research directions, aiming to provide theoretical basis and research references for the drug development of this natural product.
Yiwei convex sword leaf sedol belongs to the ether class of flavonoids, with a molecular formula of C17H18O6 and a molecular weight of 302.32. The structural characteristics of this compound include a typical flavonoid skeleton, containing multiple hydroxyl and methoxy substituents, which endow it with good polarity and biological activity basis. Its LogP value is 2.35, indicating that the molecule has moderate lipid solubility, which is beneficial for cell membrane penetration but not excessively hydrophobic, meeting the ideal lipid solubility range of most oral drugs.
The topological polar surface area (TPSA) is 69.17 Å ², and the number of hydrogen bond acceptors is 5, indicating its hydrophilicity and binding ability in intermolecular interactions. The low permeability of the blood-brain barrier suggests limited penetration ability in the central nervous system, which may reduce the risk of central toxicity. The evaluation of drug properties showed that isomyxorubicin had no hepatotoxicity, cardiotoxicity, or hERG channel inhibition, and the Ames mutagenicity test was negative, indicating high safety.
From the perspective of chemical synthesis, the complex flavonoid skeleton and multiple hydroxyl substituents of isoquercetin make its total synthesis difficult. Currently, it mainly relies on plant extraction and purification to obtain it.
Yiwei convex sword leaf saponin is mainly isolated from the root of Astragalus membranaceus. Huangqi, as a traditional Chinese medicinal herb, is widely used in various clinical formulas such as tonifying qi and stabilizing the surface, diuresis and reducing swelling. Its roots are rich in various flavonoids, among which isoquercetin is one of the important active ingredients.
The extraction process usually uses alcohol solvents (such as ethanol or methanol) for reflux extraction of dried Astragalus root powder, followed by multi-step separation and purification techniques such as liquid-liquid distribution and column chromatography (silica gel, reverse phase C18 column, etc.) to obtain high-purity isoamyl alcohol. High performance liquid chromatography (HPLC) and mass spectrometry (MS) techniques are commonly used for qualitative and quantitative analysis to ensure the quality and purity of extracts.
In recent years, the application of ultrasound assisted extraction and microwave-assisted extraction technologies has improved the extraction efficiency and yield of isoamyl alcohol, providing technical support for its large-scale production.
Yiweitu Jianye Sha Chun showed significant anti-inflammatory activity in vitro experiments. Research has shown that this compound can inhibit the expression of IL-12 p40 subunits in macrophages induced by lipopolysaccharide (LPS). IL-12, as a pro-inflammatory cytokine, plays a key role in the pathogenesis of various inflammatory diseases. By reducing the production of IL-12, isomicrobiota can effectively regulate immune responses and alleviate inflammatory reactions.
In addition, there have been preliminary reports on the regulatory effects of isomyxorubicin on other inflammatory mediators such as TNF - α and IL-6, suggesting that it may exert anti-inflammatory effects through multi-target and multi pathway synergy.
Adenoma, as a precursor lesion of various malignant tumors, is closely related to the occurrence and development of multiple abnormal signaling pathways. Yiwei convex sword leaf saponin exhibits potential anti adenoma activity by regulating multiple molecular targets associated with adenomas, such as STAT3, SIRT1, NFE2L2, etc.
The STAT3 signaling pathway plays a crucial role in tumor cell proliferation, anti apoptosis, and immune escape. Yiwei convex sword leaf saponin may block the growth signal transduction of tumor cells by inhibiting the activation of STAT3. SIRT1, as a deacetylase, participates in cellular metabolism and stress response, and its regulation helps maintain cellular homeostasis. The effect of isoproterenol on SIRT1 may mediate its anti-tumor and anti-aging effects.
In addition, NFE2L2 (NRF2) is a core transcription factor for cellular antioxidant stress, and isomorphol enhances cellular antioxidant capacity, reduces oxidative stress damage, and blocks the malignant transformation process of adenomas by activating the NFE2L2 pathway.
Some studies have shown that isomyxorubicin may have multiple effects such as regulating lipid metabolism, protecting the liver, and immune regulation, but the relevant mechanisms still need to be further elucidated.
The pharmacological effects of Yiwei convex sword leaf saponin depend on its regulation of multiple molecular targets, especially in inflammation and tumor related signaling pathways.
The multidimensional regulation of these targets demonstrates the potential of isomicroconvex clindamycin as a multi-target drug, particularly suitable for the treatment of complex diseases such as inflammatory diseases and tumors.
The pharmacological parameters of Yiwei convex Jianye Sha Chun show that it has good drug properties. The moderate molecular weight and LogP value ensure its good bioavailability and cell membrane penetration. The moderate number of TPSA and hydrogen bond receptors is beneficial for binding to target proteins.
In terms of safety, there is no hepatotoxicity, cardiotoxicity, or hERG channel inhibition, and the Ames test is negative, indicating a low risk of genetic toxicity and suitability for further drug development.
The low permeability of the blood-brain barrier suggests that isomorphol may mainly act on peripheral tissues, reducing the risk of central nervous system side effects.
At present, there is limited research on the pharmacokinetics of isoquercetin. Preliminary in vivo experiments suggest that its oral absorption is good, metabolism is stable, and it is mainly excreted through the liver metabolic pathway. Further systematic pharmacokinetic and toxicological studies are needed in the future to clarify its in vivo behavior and safe dosage range.
As an active ingredient in Astragalus membranaceus, Yi Wei Tu Jian Ye Sha Chun has shown broad clinical application prospects due to its significant anti-inflammatory and potential anti-tumor activities. Its inhibitory effect on LPS induced IL-12 p40 makes it potentially valuable in the treatment of chronic inflammatory diseases such as rheumatoid arthritis and inflammatory bowel disease.
In the field of tumor prevention and adjuvant therapy, isomicroconvex clindamycin regulates adenoma related signaling pathways through multiple targets, providing new ideas for adenoma and early tumor intervention. It has good safety and is suitable for long-term medication, especially for adjuvant treatment of chronic disease patients.
Future research should focus on the following aspects:
Through interdisciplinary collaboration, we aim to promote the clinical translation of Yiwei Convex Jianye Sha Chun and develop it into a safe and effective new natural medicine.
As a flavonoid natural product derived from Astragalus membranaceus, Yiweitu Jianye Sha Chun has shown important research and application value in the fields of anti-inflammatory and anti-tumor due to its unique chemical structure and multi-target pharmacological activity. Its good pharmacokinetic parameters and safety have laid the foundation for further drug development.
In the future, with the in-depth analysis of pharmacological mechanisms and the advancement of preclinical research, isomyxorubicin is expected to become a new candidate drug for the treatment of inflammatory diseases and precancerous lesions such as adenomas. Continuous basic research and translational medicine work will provide solid support for its clinical applications, promoting the innovative development of natural products in modern medicine.
