Protective effect on myocardial ischemia
Hyperoside can reduce the rate of myocardial apoptosis caused by hypoxia reoxygenation, inhibit the release of lactate dehydrogenase, and reduce the formation of oxygen free radicals and nitric oxide free radicals, so as to protect myocardium and reduce myocardial cell injury and apoptosis caused by ischemia-reperfusion.
Protective effect on cerebral ischemia
Hyperoside can effectively inhibit the decrease of neuronal activity induced by hypoxia glucose deprivation reperfusion injury. Its mechanism may be related to free radical scavenging and inhibition of Ca2 + And the formation of anti lipid peroxides.
Protective effect on liver and gastric mucosa.
Hyperoside has obvious protective effect on liver and gastric mucosa, and its mechanism is related to antioxidation, promoting N0 level to return to normal and increasing SOD activity.
Antispasmodic analgesic effect
Hyperoside injection is an ideal antispasmodic and analgesic drug in the treatment of primary dysmenorrhea. It has no adverse reactions such as tachycardia, mydriasis and burning sensation, except for a few side effects of drowsiness.
Hypolipidemic effect
Reducing the damage of superoxide free radicals to vascular endothelium in hyperlipidemia is conducive to the decomposition and metabolism of lipid peroxide to protect vascular endothelium.
Enhance immune function
Hyperoside can significantly promote the proliferation of spleen T and B lymphocytes in vitro, enhance the ability of T lymphocytes to produce IL-2, and has a significant dose-response relationship. Hyperoside can significantly increase the ability of macrophages to phagocytize neutrophils.
Antidepressant effect
Hypothalamic pituitary adrenal (HPA) activation is a common biological change in patients with severe depression, which is manifested by excessive secretion of adrenocorticotropic hormone (ACTH) and cortisol. Hyperoside can regulate the function of HPA axis, decrease the levels of ACTH and corticosterone, and play an antidepressant role.