Ischemia-reperfusion injury is related to excessive production and accumulation of free radicals. Scavenging oxygen free radicals is one of the key measures to reduce cerebral ischemia-reperfusion injury. The protective effects of many antioxidants such as 21 aminosteroids and salvianolic acid a have been confirmed.Propyl gallateIt is a derivative of gallic acid widely distributed in plants. It has the effects of anti platelet aggregation and vasodilation. It is a promising drug for the treatment of cardiovascular diseases. In addition, propyl gallate also has antioxidant effect, and has been widely used as an antioxidant in drugs and foods with the approval of FDA and who.
From the perspective of chemical structure, propyl gallate contains multiple free phenolic hydroxyl groups, which are very easy to be oxidized. It is a strong antioxidant. When lipid peroxidation occurs in the unsaturated fatty acids of the bio film, it can provide electrons to eliminate free radicals. It was found that propyl gallate could increase the activity of antioxidant enzymes in ischemia-reperfusion brain tissue, reduce the water content of ischemia-reperfusion brain tissue, and inhibit the formation of brain edema, indicating that the drug could reduce the production of o2-. by increasing the activity of SOD; By increasing the activity of GSH PX and cat, H2O2 catalysed by SOD can be removed in time during ischemia-reperfusion, so as to reduce the generation of Oh · and lipid free radicals and reduce the lipid peroxidation damage of brain tissue caused by ischemia-reperfusion. Its function may be to protect the activity of antioxidant enzymes by scavenging free radicals.
Lipid peroxidation caused by free radicals produced during ischemia-reperfusion is one of the main reasons for the inactivation of ATPase on cell membrane and the obstacle of ion transport. The results of this study suggest that propyl gallate may protect the activities of na+, k+-atpase in brain tissue of rats with ischemia-reperfusion through its anti lipid peroxidation, which is helpful to improve ion transport and reduce ca2+ overload and lipid peroxidation damage. Therefore, propyl gallate has a good practical prospect in the prevention and treatment of cerebral ischemia-reperfusion injury.