With the rapid development of industrialization, modern lifestyle and human ecological environment, the incidence of allergic rhinitis has a global growth trend. Its incidence rate accounts for about 5%~50% of the population. In developing countries, the prevalence of seasonal allergic rhinitis in adolescents is as high as 50%. Allergic rhinitis has a high incidence and is often accompanied by complications such as asthma, sinusitis and otitis media, which affect the learning and work efficiency of patients, lead to the decline of quality of life, cause serious harm to production and labor, and also increase the economic burden of society and individuals.

    Allergic rhinitis, also known as allergic rhinitis, is an allergic disease that occurs in nasal mucosa. It is also a common manifestation of respiratory allergy. The clinical symptoms are paroxysmal nasal congestion, including nasal itching, sneezing, runny nose, congestion of nasal mucosa, fatigue, discomfort, irritability and lack of neural recognition. It is a common and frequently occurring disease in rhinology. Modern medicine believes that allergic rhinitis is one of the rapid allergic reactions, which is a series of symptoms of allergic rhinitis due to the degranulation of the medium caused by the combination of IgE antibody and antigen, the release of histamine, bradykinin, eosinophil chemokine, chronic reactant (SRS-A) and other effects on the effector organs, resulting in telangiectasia, increased gland secretion, mucosal edema and so on.

    Experimental findingsCauliflower lactoneIt can reduce the times of scratching and sneezing and alleviate the symptoms of nasal mucus in allergic rats. According to histopathological observation, it can effectively reduce the number of infiltrating acidic granulocytes in nasal mucosa. The anti allergic rhinitis mechanism of Daphne lactone is to reduce the specific antibody IgE by inhibiting IL-4, and indirectly reduce mast cell histamine, so as to alleviate the symptoms of allergic rhinitis; On the other hand, the decrease of IL-4 causes the decrease of eosinophil infiltration in nasal mucosa. In a word, Daphne lactone reduces the specific antibody IgE by inhibiting IL-4, thus indirectly reducing the number of activated mast cells and infiltrating eosinophils, and finally achieving the goal of alleviating allergic rhinitis.