Pueraria lobata, as a kind of Chinese herbal medicine, according to the records in Shennong Materia Medica, it has the effects of relieving muscle fever, permeating measles, generating body fluid to quench thirst, raising yang to stop diarrhea and so on At present, puerarin has been widely used in the treatment of a variety of diseases. It can protect nerves, reduce blood sugar, resist oxidative stress, resist allergy, improve blood circulation, and treat osteoporosis In recent years, the anti-inflammatory effect of Puerarin has been gradually recognized by people, especially in improving the inflammatory response of cardiovascular and cerebrovascular diseases So why does the anti-inflammatory activity of Puerarin arouse the interest of scholars?

        First, the effect of Puerarin on immune cells. Puerarin not only weakened the antigen presenting ability of dendritic cells, but also inhibited the function of T lymphocytes Dendritic cells are the most powerful professional antigen-presenting cells in the body. Most of them exist in the body in an immature state When the body is infected, dendritic cells will gradually mature in the process of receiving infection stimulation, migrate from peripheral tissues to secondary lymphoid organs, and then contact with T cells to stimulate   T lymphocytes proliferate in large numbers, resulting in an immune response Li Dazhu et al. Found that heat shock eggs were loaded on spleen lymphocytes of mice in vitro   The antigen presenting ability of dendritic cells and the ability to stimulate T cell proliferation of white 60 (Hsp60) were enhanced, and the experiments in mice also showed that Hsp60 specifically activated T cells Puerarin can directly inhibit the function of dendritic cells, significantly inhibit the secretion and proliferation of T lymphocytes, effectively inhibit the immune inflammatory response, improve the endothelial relaxation function, and prevent the occurrence of atherosclerosis. This suggests that puerarin can inhibit the further amplification of inflammatory response by weakening the antigen presentation ability of dendritic cells, inhibit the secretion and proliferation of T lymphocytes, and achieve the effect of reducing endothelial dysfunction. Therefore, puerarin can prevent and treat atherosclerosis.

      Second, puerarin can affect the secretion of inflammatory factors. Inflammatory factors include CRP, ILS, TNF-a, PAI-1, adhesion molecules, etc They are involved in cardiovascular and cerebrovascular diseases, tumors and insulin   The occurrence and development of diseases related to abnormal inflammatory response, such as resistance and asthma Studies have shown that puerarin can affect the secretion of inflammatory factors and improve the inflammatory response

    To sum up,puerarin On the one hand, puerarin can inhibit the antigen presentation ability of dendritic cells and reduce the secretion and proliferation of T lymphocytes to alleviate the inflammatory response; On the other hand, it can not only directly regulate the expression of inflammatory factors, but also block nf-  The activation of κ bsignaling pathway activates jak/stat and keap1/nrf-2/aresignaling pathway, thus indirectly regulating the secretion of inflammatory factors, and finally reducing the inflammatory response At present, the occurrence and development of chronic inflammatory diseases such as cardiovascular disease, tumor, obesity and diabetes are closely related to inflammatory response. The secretion of inflammatory factors throughout the whole process of the disease Puerarin, as an effective anti-inflammatory drug, is believed to be further promoted in the medical field.