Stephanine is a kind of dibenzyl isoquinoline alkaloid isolated from the rhizome of Stephania stephensis, which has anti-inflammatory, antibacterial and immune regulating effects. In recent years, many scholars believe that it also has the function of stimulating reticuloendothelial system, activating hematopoietic tissue and promoting bone marrow proliferation.
Pneumoconiosis is one of the occupational diseases that seriously endanger the health of workers. It is a systemic disease mainly characterized by pulmonary fibrosis. There have been many reports on the research of drugs for the treatment of silicosis in clinic: the drugs such as silkepin, aluminum citrate, tetrandrine and piperaquine phosphate have not only achieved certain effects in inhibiting the progress of collagen fibers and protecting the function of alveolar macrophages in animal models, but also observed the effects of alleviating symptoms and delaying the progress of disease in clinical silicosis patients. However, there is no specific drug treatment at present. In recent years, the treatment of silicosis with stephanine has attracted the attention of many scholars. Adhering to the long-term comprehensive treatment based on stephanine has certain effects in improving pneumoconiosis symptoms, delaying the decline of lung function, preventing the progress of pneumoconiosis and improving the quality of life, with few and mild side effects.
StephanineIt can inhibit fibroblasts. Fibroblasts are cells that synthesize collagen and stroma, thus inhibiting the process of pulmonary fibrosis. Therefore, it can prevent or delay the pulmonary fibrosis process of pneumoconiosis. In addition, stephanine also has the effects of analgesia, sedation, anti-inflammatory, bacteriostasis, anti-virus and immune regulation, and has a good preventive and therapeutic effect on various hazards and complications of pneumoconiosis. At the same time, oxygen inhalation, nebulization and application of immunomodulator in comprehensive treatment are also helpful to alleviate symptoms, delay the progress of pneumoconiosis and reduce complications; Therefore, it can produce better synergistic therapeutic effect. Of course, there are some side effects of stephanine. In clinical trials, it was found that stephanine tablets have mild gastrointestinal discomfort 19 cases; Slight pigmentation in local skin and nail bed 25 For example, However, it can disappear automatically after drug withdrawal, No other side effects were found after long-term medication. Therefore, the toxic side effects of stephanine in the treatment of pneumoconiosis are small.
Stephanine tablet is a new anti pneumoconiosis drug approved by the Ministry of health in 1993. It has an inhibitory effect on fibroblasts, which synthesize collagen and stromal cells to inhibit the process of lung fibers. At the same time, it also has the function of stimulating the reticuloendothelial system and improving immune function. After 1-2 years of treatment practice, the results show that the clinical efficacy is good. Qianjintengsu tablets can alleviate cough, expectoration, asthma and other symptoms.