Colorectal cancer is one of the most common malignant tumors in the world. In the western developed countries, the incidence of malignant tumors ranks second. China has more than 170000 new cases every year, and the increasing rate of incidence is twice the world average. It is the fourth malignant tumor disease in China. How to effectively prevent and treat CRC is one of the important topics concerned by the medical community. The treatment of this disease is constantly updated with the continuous improvement of surgical techniques, fluorouracil based combined chemotherapy and radiotherapy, which brings new hope to patients. However, the chemical synthetic anti-tumor drugs used in the treatment of Western medicine generally have the disadvantages of high price and large toxic and side effects. At present, surgery, chemotherapy and radiotherapy are the three major treatment methods for colorectal cancer, but surgery will damage the viscera and organs, cause trauma and bleeding, lack of selectivity of radiotherapy and chemotherapy, have great toxic and side effects, and damage the immune function of the body. After surgery, radiotherapy and chemotherapy, combined with traditional Chinese medicine treatment, it can not only promote the recovery of the body, enhance immune function, but also continue to play an anti-cancer role, prevent recurrence and metastasis, and improve the survival rate. Therefore, it is still a problem to be solved in the treatment of CRC to find drugs with high efficiency and low toxicity. Sophora alopecuroides is a perennial herb of Sophora genus in Leguminosae. At present, it is found that Sophora alopecuroides is rich in quinoxicilline alkaloids. These alkaloids are nitrogen-containing organic basic compounds, which have obvious anticancer effect, and are one of the focuses of anticancer drug research in recent years.

    Picoline (picoline) is derived from sophora  picoline pecuraides,   50) The alkaloid monomer extracted from sophoridine belongs to quinolixidine alkaloids, but the structure of sophoridine is different from that of other alkaloids such as sophoridine and matrine. It is a three ring result and has stronger alkalinity. Sophora alopecuroides has obvious anti-inflammatory and anti-virus effects. It has the effects of clearing away heat, relieving pain, killing insects, relieving pain, calming and cooling. Its inhibitory effect on Neisseria gonorrhoeae is similar to that of penicillin. Its antibacterial activity is stronger than that of matrine. It has scavenging effects on reactive oxygen free radicals and lipid free radicals. It can effectively alleviate the inflammatory reaction of colitis mice. Studies have shown that picoline has a better effect on inhibiting tumor proliferation, and its effect on leukemia cell lines is better than that on lung cancer, liver cancer and esophageal cancer solid tumor cell lines, especially on HL-60 cell line. Sophorine inhibits the proliferation of colon cancer SW480, promotes apoptosis, inhibits the activation of jak/stat3signaling pathway, and inhibits tumor growth. Therefore, it has great application possibility and good development prospect in the treatment of colorectal cancer.

    AloperineThe successful development of Sophora alopecuroides preparation will greatly facilitate the full utilization of resources and promote economic development. At the same time, the organic combination of traditional Chinese medicine and modern molecular biotechnology is of great significance for traditional Chinese medicine to go global and carry forward traditional Chinese medicine.