It is not difficult to find that liver diseases caused by liver injury have become more and more common. Generally, liver injury can lead to liver fibrosis and cirrhosis, which are important initiating factors of hepatocarcinogenesis. The high morbidity and mortality rate is a great threat to human health. According to the existing investigation in China, there are more than 200million patients with liver diseases caused by liver injury, including about 93million HBV carriers, more than 1million new cases every year, and the treatment cost is more than 100billion yuan. The treatment of liver diseases has become a research hotspot, but so far there is no specific drug for the treatment of liver diseases, so it is necessary to find an effective and regulatory drug for the treatment of liver injury.

    As a characteristic drug in China, traditional Chinese medicine has attracted more and more attention because of its low side effects and unique advantages in protecting the liver and eliminating jaundice. The traditional Chinese medicine research on the protection of liver injury mainly includes anti endotoxin treatment, anti free radicals, promoting hepatocyte regeneration, regulating immune function, improving microcirculation and anti apoptosis. At present, many effective active substances have been developed for the treatment of liver injury. These include: licorice glycyrrhizic acid, Sophora flavescens matrine, baicalin, etc. Tianjihuang is commonly used in the treatment of acute and chronic hepatitis. Modern pharmacological studies have proved that Tianjihuang has a protective effect on immune, infectious and cholestatic liver injury.

    It has been found that the sterile aqueous solution extracted from youtianjihuang has a good effect on the SGPT decline of acute icteric, persistent, chronic and severe hepatitis and liver cirrhosis. Clinical experiments show that. Tianjihuang extract -vincetoxicoside B The effective rate was 95% for acute jaundice and chronic hepatitis, and 74% for persistent and chronic hepatitis. It was found that Tianjihuang glycoside had a good protective effect on acute liver injury induced by CCl4 or D-galactosamine in rats, and a good anti yellowing effect on jaundice liver injury induced by α - naphthalene isothiocyanate in mice. In addition, it can also inhibit the formation of liver fibrosis induced by common bile duct ligation in rats. Its anti fibrosis effect is related to its antioxidant effect and anti tnf- α secretion.