Aristolochic acid is a common component of Aristolochiae and asarum. Aristolochic acid-a is a rare substituted phenanthrolinic acid containing nitro group in many Aristolochiae plants. Aristolochic acid A is one of the main components of antibacterial and enhancing immune function. It has certain curative effects in anti infection, anti-cancer and trauma treatment, and has certain analgesic and anti-inflammatory effects.

    The medicinal materials containing aristolochic acid have been used for a long time. The commonly used Chinese medicines containing or possibly containing aristolochic acid include: Aristolochia manshuriensis, Aristolochia Aristolochia, qingmuxiang, tianxianteng, asarum, xugufeng, zhushalian, guangfangji, etc. The safety of aristolochic acid has been the focus of attention at home and abroad in recent years, and the renal damage caused by aristolochic acid has been confirmed

    AlthoughAristolochic acid AIt has anti-cancer, anti infection, anti early pregnancy and enhancing the activity of phagocytes, but its toxic dose to liver and kidney is 1000 times of the effective dose. Kidney damage caused by aristolochic acid in recent years "aristolochic acid nephropathy has been paid more and more attention in clinic and the drug use has been investigated. It would be a pity to give up the use of aristolochic acid. We might as well find a better processing method to reduce or eliminate the kidney damage toxicity of aristolochic acid.

    We know that many traditional Chinese medicines are toxic when they are used, but after processing, the toxicity is greatly reduced. In fact, studies have shown that the toxicity of aristolochic acid compounds is mainly caused by aristolochic acid A or its metabolite aristolochic lactam. Therefore, we can try to use six methods: Lime water boiling, lime water steaming, licorice juice boiling, black bean juice boiling, baking soda boiling and talc powder frying to process. The results showed that the content of aristolochic acid A in the test samples decreased significantly (by more than 30%), but the difference was significant. The results of toxicological tests showed that, compared with the raw products, the above six processed products could significantly reduce the damage to animal renal function, and the degree of reduction seemed to have a certain correlation with the content of aristolochic acid a. Therefore, the treatment of aristolochic acid containing traditional Chinese medicine represented by Aristolochia manshuriensis can reduce the content of aristolochic acid through appropriate processing methods and reduce its damage to animal renal function.