In recent years, the use of phytochemicals to treat human diseases, especially cancer and cardiovascular diseases, has been increasingly concerned by the public and the scientific community. Ginger is an important cultivated plant in Asia, especially in Southeast Asia. The Ministry of health of China listed it as one of the first batch of medicinal and edible plant resources. The phytochemical 6-gingerol is a phenolic substance extracted from ginger. It is the main component of gingerol. 6-gingerol has many biological activities, such as anti-oxidation, anti-tumor, anti-inflammatory, heart strengthening, blood pressure lowering, blood lipid lowering, blood glucose lowering, anticoagulation and so on. There are research findings,6-gingerol It has important application possibility in the treatment of cerebral ischemia.

      Cerebral ischemia is the second leading cause of death in the world. There are 4million people dying of cerebral ischemia every year in the world, and its high mortality is second only to heart disease. Although the prevalence of cerebral ischemia decreased, the absolute number of people suffering from cerebral ischemia began to increase due to the increase of the average age of the population. Cerebral ischemia affects the whole society, occupies social resources and brings heavy social burden. At the same time, the high cost of treating cerebral ischemia lies not only in the emergency clinical rescue measures, but also in the subsequent recovery period. Free radical injury, ion balance disorder, excitatory amino acid toxicity, inflammatory injury and apoptosis are closely related to the course of stroke. Neuronal death after cerebral ischemia and hypoxia includes necrosis and apoptosis. The central area of severe hypoxia injury has been mainly necrotic. It is particularly important to study the mechanism of delayed neuroprotection in the peripheral area and find effective therapeutic drugs. It has been found that 6-gingerol can protect rats from focal cerebral ischemia injury by inhibiting lipid peroxidation.

      It is believed that with the development of biotechnology and chemical technology, people will further explore the possibility of 6-gingerol in the treatment of cerebral ischemia.