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Home >  Botanical Source >  Hedera ingredients > Hederacoside C

Synonym name: Akebiasaponin PK; Glycoside L-H2; Kalopanaxsaponin B; Tauroside H2; Hederoside H1; Akeboside Sth; Astrantiasaponin H; Hederasaponin C; Hederacaucaside D; Pulsatillasaponin II; Pericarpsasaponin Pk; Pulsatillasaponin F; Hederacol
Catalogue No.: BP0708
Cas No.: 14216-03-6
Formula: C59H96O26
Mol Weight: 1221.39
Botanical Source: Hedera helix(Hedera nepalensis var. sinensis

Purity: 40%, 80%~99%
Analysis Method: HPLC-DAD or/and HPLC-ELSD
Identification Method: Mass, NMR
Packing: Drum, Aluminum plastic compound bag

Can be supplied from grams, kilograms, up to Tons.


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Typical COA:

            Hederacoside C-COA.pdf


References

1, Pharmacokinetics of hederacoside C, an active ingredient in AG NPP709, in rats.
Xenobiotica. 2013 Nov;43(11):985-92. 
Abstract
1. Hederacoside C (HDC) is one of the active ingredients in Hedera helix leaf extract (Ivy Ex.) and AG NPP709, a new botanical drug to treat acute respiratory infection and chronic inflammatory bronchitis. However, information regarding its pharmacokinetic properties remains limited. 2. Here, we report the pharmacokinetics of HDC in rats after intravenous administration of HDC (3, 12.5, and 25 mg/kg) and after oral administration of HDC, Ivy Ex., and AG NPP709 (equivalent to 12.5, 25, and 50 mg/kg HDC). 3. Linear pharmacokinetics of HDC were identified upon its intravenous administration at doses of 3-25 mg/kg. Intravenous administration of HDC results in relatively slow clearance (1.46-2.08 mL/min/kg) and a small volume of distribution at steady state (138-222 mL/kg), while oral administration results in a low absolute oral bioavailability (F) of 0.118-0.250%. The extremely low F of HDC may be due to poor absorption of HDC from the gastrointestinal (GI) tract and/or its decomposition therein. 4. The oral pharmacokinetics of HDC did not differ significantly among pure HDC, Ivy Ex., and AG NPP709.





Hederacoside C

Hederacoside C



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