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Name: Fenugreek Root Extracts

Catalog No.: BPE004

Botanical SourceAstragalus Root

Solvents for extracting: Purified water, Ethanol

Appearance: Tan powder

Solubility: Water

Active Ingredients: 4-Hydroxyisoleucine(20%, 40%); Trigonelline;  soluble fiber

Packing: Drum, Aluminum plastic compound bag
Can be supplied from kilograms to Tons.


The typical COA:

                 L-4-Hydroxyisoleucine(20%)-COA



The novel free amino acid 4-hydroxyisoleucine, has been identified in tiny quantities in the common spice fenugreek seed, for over a decade. But 4-hydroxyisoleucine was never concentrated into a commercially available product, due to difficulties of manufacture. More recently, this technology barrier has been broken, and standardized 4-hydroxyisoleucine extracts are now available on a commercial scale. Thus you will now see this ingredient making its way to market in various diet formulas.


Several studies show that the free amino acid 4-hydroxyisoleucine plays a valuable role in insulin-promotion and glucose regulation. 4-hydroxyisoleucine stimulates insulin secretion, thereby limiting the extent to which blood glucose (the glycemic index) is elevated. Elevated blood glucose after meals leads to increased production of body fat. 4 hydroxyisoleucine promotes insulin secretion and inhibits the rise of blood glucose, thus helping to reduce body fat production. 4 -hydroxyisoleucine exhibits a specific effect on the islets of Langerhans in the pancreas. These cells are directly responsible for insulin production.


Most significantly, the effect of 4-hydroxyisoleucine is glucose dependent. The higher the level of blood glucose, the greater the insulin-promoting response elicited by 4 hydroxyisoleucine. Thus 4-hydroxyisoleucine exhibits a significant regulating effect, which corresponds with the insulin needs of the body at any given time. This makes this compound “adaptogenic,” responding to the particular needs of the body at any given time.


Fenugreek has a long history of folk use throughout Asia and the Middle east as an anti-diabetic, to soothe stomach ulcers, to eliminate catarrh in the upper respiratory tract, to promote lactation, and as a poultice for treating various skin conditions. Much science on fenugreek has focused on the cholesterol-lowering, blood lipid-lowering and anti-diabetic activities of the seed. These activities appear directly linked to the presence of soluble fibers, most notably galactomannans. The galactomannans have additionally been shown to possess fat-sequestering properties, thereby binding directly to dietary fat and reducing its absorption into the body. Furthermore, anti-diabetic properties of fenugreek seed are linked to the presence of a novel free amino acid, 4 hydroxyisoleucine.


In addition, 4-hydroxyisoleucine prove a significant insulin-promoting material of benefit to anyone who desires to regulate blood glucose. In non insulin-dependent diabetics, standardized 4-hydroxyisoleucine extracts can help to maintain a stable glucose level. Additionally, 4-hydroxyisoleucine is of use to those who wish to reduce weight gain, and for athletes whose insulin demands typically exceed those of non-athletes.



Fenugreek Root Extracts

Fenugreek Root Extracts



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