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Alpha-Mangostin
Synonyms: 伪-mangostin; 1,3,6-Trihydroxy-7-methoxy-2,8-bis(3-methyl-2-butenyl)-9H-xanthen-9-one
Molecular Formula: C24H26O6
Molecular Weight : 410.46 
CAS Number: 6147-11-1
Botanical Source: Mangosteen(GARCINIA MANGOSTANA)
Catalogue No.: M07045
Purity: > 95%, 98%,99% by HPLC
Package: 0.1g, 1g, 10g, 100g,1kg,10kg...
Remark: In stock, customized for large scale.
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Mangostin is a natural organic compound isolated from various parts of the mangosteen (Garcinia mangostana). It is a yellow crystalline solid with a xanthone core structure. Mangostin and a variety of other xanthones from mangosteen have been investigated for biological properties including antioxidant, anti-bacterial, anti-inflammatory, and anticancer activities.
References
1. "Antioxidant xanthones from the pericarp of Garcinia mangostana (Mangosteen)". J. Agric. Food Chem. 2006,54 (6): 2077-82
Mangosteen is a plant native to Southeast Asia. The fruits are used in traditional medicine to treat skin infections, wounds,and diarrhea. Recent studies have revealed that xanthones from the fruit hulls exhibit antibacterial (3), antifungal (4), and antiinflammatory (5) properties. Alpha-mangostin, a xanthone, inhibited growth of human leukemia HL60 cells (1) (6), reduced the synthesis of prostaglandins (5), and prevented oxidative damage of LDL (7) in vitro. There is also preliminary evidence that alpha- and gamma-mangostins act as histamine and serotonin receptor blockers (8), and also inhibit HIV-1 protease (9). Garcinone E, another xanthone, exerts cytotoxic effects against human hepatocellular carcinoma cells (10). Extract from the pericarp of mangosteen has antiproliferative, antioxidative, and apoptotic effects against human breast cancer SKBR3 cells (11).
References
(1) Matsumoto K, et al.Induction of apoptosis by xanthones from mangosteen in human leukemia cell lines. J Nat Prod 2003; 66(8):1124-1127.
(2) Suksamrarn S, et al. Xanthones from the green fruit hulls of Garcinia mangostana. J Nat Prod 2002; 65(5):761-763.
(3) Suksamrarn S, et al. Antimycobacterial activity of prenylated xanthones from the fruits of Garcinia mangostana. Chem Pharm Bull (Tokyo) 2003; 51(7):857-859.
(4) Gopalakrishnan G, Banumathi B, Suresh G. Evaluation of the antifungal activity of natural xanthones from Garcinia mangostana and their synthetic derivatives. J Nat Prod 1997; 60(5):519-524.
(5) Nakatani K, et al. Inhibition of cyclooxygenase and prostaglandin E2 synthesis by gamma-mangostin, a xanthone derivative in mangosteen,in C6 rat glioma cells. Biochem Pharmacol 2002; 63(1):73-79.
(6) Matsumoto K, et al. Preferential target is mitochondria in alpha-mangostin-induced apoptosis in human leukemia HL60 cells. Bioorg Med Chem 2004; 12(22):5799-5806.
(7) Williams P, et al. Mangostin inhibits the oxidative modification of human low density lipoprotein. Free Radic Res 1995; 23(2):175-184.
(8) Chairungsrilerd N, et al. Histaminergic and serotonergic receptor blocking substances from the medicinal plant Garcinia mangostana. Planta Med 1996; 62(5):471-472.
(9) Chen SX, Wan M, Loh BN. Active constituents against HIV-1 protease from Garcinia mangostana. Planta Med 1996; 62(4):381-382.
(10) Ho CK, Huang YL, Chen CC. Garcinone E, a xanthone derivative, has potent cytotoxic effect against hepatocellular carcinoma cell lines.Planta Med 2002; 68(11):975-979.
(11) Moongkarndi P, et al. Antiproliferation, antioxidation and induction of apoptosis by Garcinia mangostana (mangosteen) on SKBR3 human breast cancer cell line. J Ethnopharmacol 2004; 90(1):161-166.
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