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Epigallocatechin gallate (EGCG)
Synonyms: (2R,3R)-2-(3,4,5-Trihydroxyphenyl)-3,4-dihydro-1(2H)-benzopyran-3,5,7-triol 3-(3,4,5-trihydroxybenzoate); (−)-cis-3,3',4',5,5',7-Hexahydroxy-flavane-3-gallate
CAS No. : 989-51-5
Mol. Formula: C22H18O11 
Mol. Weight: 458.38
Botanical Source: Green Tea
Catalogue No.: E07018
Purity: >95%,98%,99% by HPLC
Package: 0.1g, 1g,10g, 100g,1kg,10kg...ton
Remark: In stock, customized for large scale.
Package and quantity according to customer's detail requirement.
After optimizing the process repeatedly, manufacturing with the green environmental protection and the non-toxic solvent,the product purity and yield are enhanced and the cost is reduced sharply. High-purity EGCG production process of our company has been obtained the significant breakthrough,thus leads the application of high-purity EGCG to break through the previous limit of the excessively high cost.
We supply high purity EGCG, EGC and ECG in commercial scale,the purity>98%,99% by HPLC,customized packaging.
Properties: Epigallocatechin gallate possess the most potent antioxidant activity of the catechins.
Epigallocatechin gallate may provide health effects by protecting our cells from oxidative damage from free radicals. A number of chronic disease have been associated with free radical damage, including cancer, arteriosclerosis, heart diseases and accelerated aging. Epigallocatechin gallate interferes with many enzyme systems: it inhibits fast-binding and reversible fatty acid synthase, increases tyrosine phosphorylation of the insulin receptor, activation of ornithine decarboxylase.
Epigallocatechin gallate can protect the DNA in the human cells from ultraviolet and visible radiation-induced damage.
Epigallocatechin gallate may be effective in promoting fat oxidation and lowering body weight.
Description: Epigallocatechin gallate belongs to the family of catechins. It contains 3 phenol rings and has very strong antixoidant properties.
Distribution: Epigallocatechin gallate is the main active component if green tea leaves. Black tea leaves also contain epigallocatechin gallate but in much lower quantities. That's because black tea leaves are fermented, during which many of the cathechins are oxidized to darker coloured molecules (theaflavin and thearubigen).
Safety: Green tea consumption of as much as 20 cups per day has not been assoiated with any significant side effects. Acute studies reported the oral LD50 of EGCG in mice was 2170mg/kg bw.
 Dietary fats, teas, dairy, and nuts--- potential functional foods for weight control.pdf
Green tea polyphenol (?-epigallocatechin-3-gallate treatment of human skin inhibits ultraviolet radiation-induced oxidative stress.pdf
Treatment of green tea polyphenols in hydrophilic cream prevents UVB-induced oxidation of lipids and proteins, depletion of antioxidant enzymes and phosphorylation of MAPK proteins in SKH-1 hairless mouse.pdf
Green tea and its polyphenolic catechins---- medicinal uses in cancer and noncancer applications.pdf
The Role of Tea in Human Health.pdf
EGCG and HIV
There has been some research investigating the benefit of EGCG from green tea in the treatment of HIV infection. One study examined the molecular binding of ECGC to the CD4 receptor molecule on human lymphocytes. The CD4 receptor is the site where the HIV virus attaches to a cell before infecting it. To bind to CD4, HIV uses its own receptor gp120. The study found "clear evidence of high-affinity binding of EGCG to the CD4 molecule" and "inhibition of gp120 binding to human CD4+ T cells." [3][4] The mechanism is very similar to a new class of anti-HIV medications, the entry inhibitors. For reasons not yet understood, EGCG seems to have an inhibitory effect on other steps of the HIV lifecycle, including suppression of reverse-transcriptase concentration and decreased protease kinetics.[5] These effects have only been observed in laboratory studies, not in HIV+ individuals. The concentrations of EGCG used in the studies could not be reached by drinking green tea. More study into EGCG and HIV is currently underway.[6]
References:
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Neurodegeneration in autoimmune demyelination: Recent mechanistic insights reveal novel therapeutic targets. Orhan Aktas, Sonia Waiczies, Frauke Zipp [1]
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Williamson MP, McCormick TG, Nance CL, Shearer WT. Epigallocatechin gallate, the main polyphenol in green tea, binds to the T-cell receptor, CD4: Potential for HIV-1 therapy. J Allergy Clin Immunol. 2006 Dec;118(6):1369-74. Epub 2006 Oct 13. PMID: 17157668
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Hamza A, Zhan CG. How can (-)-epigallocatechin gallate from green tea prevent HIV-1 infection? Mechanistic insights from computational modeling and the implication for rational design of anti-HIV-1 entry inhibitors. J Phys Chem B. 2006 Feb 16;110(6):2910-7. PMID: 16471901
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Yamaguchi K, Honda M, Ikigai H, Hara Y, Shimamura T. Inhibitory effects of (-)-epigallocatechin gallate on the life cycle of human immunodeficiency virus type 1 (HIV-1). Antiviral Res. 2002 Jan;53(1):19-34. PMID: 11684313
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For more references,please contact us.
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