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Home >  Botanical Source >  Biflavones > Amentoflavone

Synonym name:
Catalogue No.: BP0161
Cas No.: 1617-53-4
Formula: C30H18O10
Mol Weight: 538.464
Botanical Source: Metasequoia glyptostroboides, Viburnum prunifolium, Podocarpus gracilior, Garcinia livingstonei, Selaginella willdenowii, Rhus succedanea, Garcinia multiflora, Ginkgo biloba, Cupressocyparis leylandii, Cryptomeria japonica, Amentotaxus formos

Purity: 90%~99%
Analysis Method: HPLC-DAD or/and HPLC-ELSD
Identification Method: Mass, NMR
Packing: Brown vial or HDPE plastic bottle
Can be supplied from milligrams to grams.

Inquire for bulk scale.(Upto Kilograms scale, for 90%~95% upto Ton).

Typical COA:
         Amentoflavone-COA.pdf

Amentoflavone is a constituent of a number of plants with medicinal properties, including Ginkgo bilobaChamaecyparis obtusa (hinoki), Hypericum perforatum (St. John’s Wort)[1] or Xerophyta plicata.[2]

It is a biflavonoid (bis-apigenin coupled at 8 and 3' positions).
Amentoflavone can interact with many other medications by being a potent inhibitor of CYP3A4 and CYP2C9, which are proteins used for drug metabolism in the body.[3] It is also an inhibitor of human cathepsin B.[1] 
Amentoflavone has demonstrated some antimalarial activity in trials[4] significant affinities towards the delta-1, kappa opioid receptors (as an antagonist)[5] and the allosteric (benzodiazepine) site on the GABAA receptors. (As a negative allosteric modulator) [6]

References

  1. a b Pan X, Tan N, Zeng G, Zhang Y, Jia R (October 2005). "Amentoflavone and its derivatives as novel natural inhibitors of human Cathepsin B". Bioorg. Med. Chem. 13 (20): 5819–25.doi:10.1016/j.bmc.2005.05.071PMID 16084098.
  2. ^ Biflavonoids in the primitive monocots Isophysis tasmanica and Xerophyta plicata. Christine A. Williams, Jeffrey B. Harborne and Francisco A. Tomas-Barberan, Phytochemistry, 1987, Volume 26, Issue 9, Pages 2553–2555, doi:10.1016/S0031-9422(00)83875-3
  3. ^ Kimura Y, Ito H, Ohnishi R, Hatano T (January 2010). "Inhibitory effects of polyphenols on human cytochrome P450 3A4 and 2C9 activity". Food Chem. Toxicol. 48 (1): 429–35.doi:10.1016/j.fct.2009.10.041PMID 19883715.
  4. ^ http://pubchem.ncbi.nlm.nih.gov/assay/assay.cgi?aid=1445
  5. ^ Katavic PL, Lamb K, Navarro H, Prisinzano TE. (August 2007). "Flavonoids as opioid receptor ligands: identification and preliminary structure-activity relationships.". J Nat Prod. 70 (8): 1278-82.PMID 17685652.
  6. ^ PMID=12824018    From Wikipedia, the free encyclopedia
Amentoflavone

Amentoflavone



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